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Chemistry Publications

Yao, Z.; Zhang, B. S.; Steinhardt, R. C.; Mills, J. H.; Prescher, J. A. Multicomponent bioluminescence imaging with an extended pi-luciferin. J. Am. Chem. Soc., 2020, 142, 14080. DOI: 10.1021/jacs.0c01064

Kerr, W. G.; Pedicone, C.; Dormann, S. D.; Pacherille, A.; Chisholm, J. D. “Small Molecule Targeting of SHIP1 and SHIP2.” Biochem. Soc. Trans. 2020, 48, 291-300. DOI:10.1042/BST20190775.

Pedicone, C., Fernandes, S., Dungan, O. M., Dormann, S. M., Viernes, D. R., Adhikari, A. A., Choi, L. B., De Jong, E., Chisholm, J.D. and Kerr, W.G. "Pan-SHIP1/2 inhibitors promote microglia effector functions essential for CNS homeostasis." J. Cell Sci. 2020, 133, jcs238030. DOI:10.1242/jcs.238030.

Moser, B. A.; Escalante-Buendia, Y; Steinhardt, R. C.; Rosenberger, M. Cassaidy, B.; Naorem, N. Chon, A. C.; Nguyen, M.; Tran, N.; Esser-Kahn, A. P. Small Molecule NF-kB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants. ChemRxiv

Wu. M.; Moser, B. A.; Steeves, T. M.; Figueroa, A.; Wallace, B. M.; Kim, S. T.; Esser-Kahn, A. P.; Steinhardt, R. C. Photon upconversion for the enhancement of microfluidic photochemical synthesis. RSC Adv., 2019, 9, 26172–26175.

Kimani, F.; Kim, S. -M.; Steinhardt, R. C.; Esser-Kahn, A. P. Correlating the Structure and Reactivity of a Contact Allergen, DNCB, and its Analogs to Sensitization Potential. Bioorg. Med. Chem. Lett., 2019,

Dao TP, Martyniak B, Canning AJ, Lei Y, Colicino EG, Cosgrove MS, Hehnly H, Castañeda CA*. (2019) ALS-linked mutations affect UBQLN2 oligomerization and phase separation in a position- and amino acid-dependent manner. Structure. 27: 937-951. DOI: 10.1016/j.str.2019.03.012.

Mahajani, N. S.; Meador, R. I. L.; Smith, T. J.; Canarelli, S. E.; Adhikari, A. A.; Shah, J. P.; Russo, C. M.; Wallach, D. R.; Howard, K. T.; Millimaci, A. M.; Chisholm, J. D. “Ester Formation via Symbiotic Activation Utilizing Trichloroacetimidate Electrophiles” J. Org. Chem. 2019, 84, 7871-7882. DOI:10.1021/acs.joc.9b00745

Suzuki, T.; Chisholm, J. D. "Friedel-Crafts Alkylation of Indoles with Trichloroacetimidates." Tetrahedron Lett., 2019, 60, 1325-1329. DOI:10.1016/j.tetlet.2019.04.007

Suzuki, T.; Mate, N. A.; Adhikari, A. A.; Chisholm, J. D. "Dialkylation of Indoles with Trichloroacetimidates to access 3,3-Disubstituted Indolenines." Molecules 2019, 23, 4143-4158. DOI:10.3390/molecules24224143

Yiran Y, Jones HB, Dao TP, Castañeda CA*. (2019) Single amino acid substitutions in stickers, but not spacers, substantially alter UBQLN2 phase transitions and dense phase material properties. Journal of Physical Chemistry B. 123: 3618-3629. DOI: 10.1021/acs.jpcb.9b01024.

Cover of ChemCatChem journal

Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity, (ChemCatChem 5/2019), Dr. Elizabeth A. Caselle, Jennifer H. Yoon, Sagar Bhattacharya, Joel J. L. Rempillo , Zsófia Lengyel, Dr. Areetha D'Souza, Dr. Yurii S. Moroz, Patricia L. Tolbert, Dr. Alexander N. Volkov, Prof. Dr. Marcello Forconi, Prof. Dr. Carlos A. Castañeda, Prof. Dr. Olga V. Makhlynets, Prof. Dr. Ivan V. Korendovych,

Moser, B. A.; Steinhardt, R. C.; Escalante-Buendia, Y.; Bolt, D. A.; Barker, K. M.; Yoo, S.; McGonnigal, B. G.; Esser-Kahn, A. P. Immune potentietor for increased safety and improved protection of vaccines by NF-kB. bioRxiv DOI:

Tom, J. K.; Albin, T. J.; Manna, S.; Moser, B. A.; Steinhardt, R. C.; Esser-Kahn, A. P. Applications of Immunomodulatory Immune Synergies to Adjuvant Discovery and Vaccine Development. Trends Biotechnol., 2019, DOI:

Mahajani, N. S.; Chisholm, J. D. "Promoter Free Allylation of Trichloroacetimidates with Allyltributylstannane Under Thermal Conditions to Access the Common 1,1’-Diarylbutyl Pharmacophore." Org. Biomol. Chem. 2018, 16, 4008-4012. DOI:10.1039/C8OB00687c

Dao TP, Kolaitis R-M, Kim HJ, O’Donovan K, Martyniak B, Colicino E, Hehnly H, Taylor JP, Castañeda CA*. (2018) Ubiquitin modulates liquid-liquid phase separation of UBQLN2 via disruption of multivalent interactions. Molecular Cell. 69: 965-978. DOI: 10.1016/j.molcel.2018.02.004.

Chepurny OG, Bonaccorso RL, Leech CA, Wöllert T, Langford GM, Schwede F, Roth CL, Doyle RP, Holz GG. Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors. Scientific Reports. 2018; 8(1):3749.

Brubaker, K., Garewal, A., Steinhardt, R.C. et al. Bio-inspired counter-current multiplier for enrichment of solutes. Nat Commun 9, 736 (2018).

Mietlicki-Baase EG, Liberini CG, Workinger JL, Bonaccorso RL, Borner T, Reiner DJ, Koch-Laskowski K, McGrath LE, Lhamo R, Stein LM, De Jonghe BC, Holz GG, Roth CL, Doyle RP, Hayes MR. A vitamin B12 conjugate of exendin-4 improves glucose tolerance without associated nausea or hypophagia in rodents. Diabetes, obesity & metabolism, 2018, 20, 1223-1234.

Steinhardt, R. C.; Hiew, S.; Mohapatra, H.; Nguyen, D.; Oh, Z.; Truong, R.; Esser-Kahn, A. P. Cooperative CO2 binding by a bifunctional guanidine and bifunctional alcohol. ACS Cent. Sci. 2017, 3, 1271-1275.

Steinhardt, R. C.‡; Steeves, T. S.‡; Wallace, B. M.; Moser, B.; Fishman, D. A.; Esser-Kahn, A. P. Photothermal nanoparticle initiation enables radical polymerization and yields unique, uniform microfibers with broad spectrum light. 2017, ACS Appl. Mater. Interfaces 2017, 44, 39034-39039.

Gumbleton, M.; Sudan, R.; Fernandes, S.; Engelman, R. W.; Russo, C. M.; Chisholm, J. D.; Kerr, W. G. "Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival." Sci. Signal. 2017, 10, eaam5353. DOI:10.1126/scisignal.aam5353

Steinhardt, R. C.; Rathbun, C. M.; McCutcheon, D. C.; Krull, B.; Porterfield, W. B.; Furche, F.; Prescher, J. A. Brominated luciferins are versatile bioluminescent probes. ChemBioChem 2017, 18, 96–100.

Moser, B. A.; ‡ Steinhardt, R. C.‡; Esser-Kahn, A. P. Surface coating of nanoparticles reduces background inflammatory activity while increasing particle uptake and delivery. ACS Biomater. Sci. Eng. 2016, 3, 206–213. DOI: 10.1021/acsbiomaterials.6b00473 ‡ denotes equal contribution

Adhikari, A. A.; Chisholm, J. D. "Lewis Acid Catalyzed Displacement of Trichloroacetimidates in the Synthesis of Functionalized Pyrroloindolines." Org. Lett. 2016, 18, 4100-4103. DOI:10.1021/acs.orglett.6b02024

Castañeda CA*, Chaturvedi A, Camara CM, Curtis JE, Krueger S, Fushman D. (2016) Linkage-specific conformational ensembles of non-canonical polyubiquitin chains. Phys Chem Chem Phys 18: 5771-5788. DOI: 0.1039/C5CP04601G.

Steinhardt, R. C.; O’Neill, J. A.; McCutcheon, D. C; Rathbun, C. M.; Prescher, J. A. Design and synthesis of an alkynyl luciferin analogue for bioluminescence imaging. Chem. Eur. J. 2016, 22, 3671–3675. doi: 10.1002/chem.201503944

McCutcheon, D. C.; Paley, M. A.; Steinhardt, R. C.; Prescher, J. A. Expedient synthesis of electronically-modified luciferins for bioluminescence imaging. J. Am. Chem. Soc. 2012, 134, 7604-7607.

Castañeda CA, Liu J, Chaturvedi A, Nowicka U, Cropp TA, Fushman D. (2011) Nonenzymatic assembly of natural polyubiquitin chains of any linkage composition and isotopic labeling scheme. J. Am. Chem. Soc. 133: 17855-17868. DOI: 10.1021/ja207220g.

Hirschi, A.; Cecchini, M.; Steinhardt, R. C.; Schamber, M. R.; Dick, F. A.; Rubin, S. M. An overlapping kinase and phosphatase docking site regulates activity of the Retinoblastoma protein. Nature Struct. Mol. Biol. 2010, 17, 1051-1057. DOI: 10.1038/nsmb.1868

Halpenny, G. M.; Steinhardt, R. C.; Okialda, K. A.; Mascharak, P. K. Characterization of pHEMA-based hydrogels that exhibit light-induced bactericidal effect via release of NO. J. Mater. Sci. Mater. Med. 2009, 20, 2353-2360. DOI:10.1007/s10856-009-3795-0

Mizisin, A. P.; Steinhardt, R. C.; O’Brien, J. S.; Calcutt, N. A. TX14(A), a prosaposin-derived peptide, reverses established nerve disorders in streptozotocin-diabetic rats and prevents them in galactose-fed rats. J. Neuropath. Exp. Neurol. 2001, 60, 953-960.