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Heidi Hehnly

Heidi Hehnly

Heidi Hehnly

Renée Crown Professor in the Sciences and Mathematics and Associate Professor


236 Life Sciences Complex
Office: 315.443.2159



Social/Academic Links

Research Interests

Our research interests include understanding the interface between cytoskeletal dynamics and membrane transport and defining how they co-regulate one another to control essential cellular processes such as cell division, fate, and polarity.

Previous Academic Appointments

Assistant Professor, SUNY Upstate Medical College, Syracuse, NY (2015-2018)

Selected Publications

Aljiboury A, Hehnly H. The centrosome–diverse functions in fertilization and development across species. Journal of Cell Science. 2023 Dec 1;136(23).

Aljiboury A*, Eric Ingram*, Nikhila Krishnan*, Favour Ononiwu*, Debadrita Pal*, Julie Manikas, Christopher Taveras, Nicole Hall, Jonah Da Silva, Judy Freshour, and Heidi Hehnly. Rab8-, Rab11-, and Rab35-dependent mechanisms coordinating lumen and cilia formation during Left-Right Organizer development. PLOS Genetics. 2023 *equal contributions. PMID: 37186603

Aljiboury A, Mujcic A, Curtis E, Cammerino I, Magny D, Lan Y, Bates M, Freshour J, Ahmed-Braimeh YH, Hehnly H. Pericentriolar Matrix (PCM) Integrity Relies on Cenexin and Polo-Like Kinase (PLK)1. Molecular Biology of the Cell. 2022. PMID:35609215

Krishnan N, Swoger M, Rathbun LI, Fioramonti PJ, Freshour J, Bates M, Patteson AE, Hehnly H. Rab11 Endosomes and Pericentrin Coordinate Centrosome Movement During Pre-Abscission in Vivo. Life Sci Alliance. 2022. PMID:35304423

Swoger M, Gupta S, Charrier E, Bates M, Hehnly H, Patteson AE. Vimentin Intermediate Filaments Mediate Cell Morphology on Viscoelastic Substrates. ACS App Bio Mater. 2022. PMID:3499547

Riley JE, Fioramonti PJ, Rusnock AK, Hehnly H, Castaneda CA. ALS-Linked Mutations Impair UBQLN2 Stress-Induced Bimolecular Condensate Assembly in Cells. J Neurochem. 2021. PMID:34129687

Rathbun L., Aljiboury A., Bai X., Hall NA., Manikas J., Amack JD., Bembenek JN., Hehnly H., PLK1- and PLK4-Mediated Asymmetric Mitotic Centrosome Size and Positioning in the Early Zebra-fish Embryo, Current Biology (2020),

Rathbun, L.I., Colicino, E.G., Manikas, J. et al. Cytokinetic bridge triggers de novo lumen formation in vivo. Nat Commun 11, 1269 (2020).

Colicino EG, Stevens K, Curtis E, Rathbun L, Bates M, Manikas J, Amack J, Freshour J, Hehnly H. Chromosome misalignment is associated with PLK1 activity at cenexin-positive mitotic centrosomes. Molecular Biology of the Cell. 2019. PMID:31042116

Dao TP, Martyniak B, Canning AJ, Lei Y, Colicino EG, Cosgrove MS, Hehnly H, Castañeda CA*. (2019) ALS-linked mutations affect UBQLN2 oligomerization and phase separation in a position- and amino acid-dependent manner. Structure. 27: 937-951. DOI: 10.1016/j.str.2019.03.012.

Dao TP, Kolaitis R-M, Kim HJ, O’Donovan K, Martyniak B, Colicino E, Hehnly H, Taylor JP, Castañeda CA*. (2018) Ubiquitin modulates liquid-liquid phase separation of UBQLN2 via disruption of multivalent interactions. Molecular Cell. 69: 965-978. DOI: 10.1016/j.molcel.2018.02.004.

Dao TP, Kolaitis RM, Kim HJ, O'Donovan K, Martyniak B, Colicino E, Hehnly H, Taylor JP, Castañeda CA. Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions. Molecular Cell. 2018. Read article.

Colicino EG, Garrastegui AM, Freshour J, Santra P, Post DE, Kotula L, Hehnly H. Gravin regulates centrosome function through PLK1. Molecular Biology of the Cell. 2018. Read article.

Taneja N, Fenix AM, Rathbun L, Millis BA, Tyska MJ, Hehnly H, Burnette DT. Focal adhesions control cleavage furrow shape and spindle tilt during mitosis. Scientific Reports 2016. Read article.

Vertii A, Ivshina M, Zimmerman W, Hehnly H, Kant S, Doxsey S. The Centrosome Undergoes Plk1-Independent Interphase Maturation during Inflammation and Mediates Cytokine Release. Developmental Cell 2016. Read article.

Hung H, Hehnly H¥, Doxsey S¥. The mother centriole protein, cenexin, modulates symmetric lumen formation through spindle orientation. Current Biology 2016 (¥) depicts co-corresponding author. Read article.

Hehnly H*, Canton D*, Bucko P, Langeberg LK, Ogier L, Gelman I, Santana LF, Wordeman L, Scott JD. An Aurora A-Plk1 kinase scaffold depleted in testicular seminomas impacts mitotic spindle orientation in germline stem cells. eLIFE. 2015 depicts co-first authorship. Read article.

Elisa de Souza E, Hehnly H, Perez AM, Vaz Meirelles G, Costa Smetana JH, Doxsey S, Kobarg J., Human Nek7-interactor RGS2 is required for mitotic spindle organization. Cell Cycle. 2015 Feb 9:0. [Epub ahead of print] PMID: 25664600. Read article.

Chen CT*, Hehnly H*, Yu Q*, Farkas D, Zheng G, Redick SD, Hung HF, Samtani R, Jurczyk A, Akbarian S, Wise C, Jackson A, Bober M, Guo Y, Lo C, Doxsey S. A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation. Current Biology. 2014 2014 Oct 6;24(19):2327-34. PMID: 25220058 depicts co-first authorship *Current Biology Commentary titled “Pericentrin: critical for spindle orientation.”. Read article.

Hehnly H and Doxsey S, Rab11 endosomes contribute to mitotic spindle organization and orientation. Developmental Cell. 2014 Mar 10;28(5):497-507. PMID: 24561039 *Awarded Cover Image. *Developmental Cell Commentary titled “Spindlegate: the biological consequences of disrupting traffic.”. Read article.

Hehnly H, Chen CT, Powers C, Lui HL, and Doxsey S, The Centrosome regulates the Rab11-dependent recycling endosome pathway at appendages of the mother centriole. Current Biology. 2012 Oct 23; 22(20):1944-50. PMID: 22981775 *Featured in Faculty 1000 *Featured in Nature Reviews Molecular Cell Biology. Read article.

Hehnly H, Xu W, Chen J, and Stamnes M (2010) Cdc42 regulates microtubule-dependent Golgi positioning. Traffic. 11(8): 1067-78; PMID: 20525016 *Awarded Cover Image. Read article.

Hehnly H, Longhini K, Chen J, and Stamnes M (2009) Retrograde Shiga toxin trafficking is regulated by ARHGAP21 and Cdc42. Molecular Biology of the Cell. 20(20):4303-12 PMID: 19692570. Read article.

Hehnly H, Sheff D, Stamnes M (2006) Shiga toxin facilitates its retrograde transport by modifying microtubule dynamics. Molecular Biology of the Cell. 17(10): p.4379-89 PMID: 16885418. Read article.