Orange Alert

Aaron Wolfe

Aaron Wolfe

Aaron Wolfe

Affiliated Faculty, Chief Science Officer, Ichor Therapeutics INC







Syracuse University Aug. 2011-Oct. 2018
PhD. Structural Biology, Biochemistry, and Biophysics Doctoral Program (SB3)
Syracuse, NY

Wharton University of Pennsylvania Sept. 2008-May 2010
Entrepreneurship Certificate Program
Philadelphia, PA

SUNY Environmental College of Science and Forestry Sept. 2004-Dec. 2006
B.S. Biotechnology (cum laude)
Syracuse, NY

Selected Publications:

C60 in olive oil causes light-dependent toxicity and does not extend lifespan in mice
Grohn K, Moyer B, Wortel D, Fisher C, Lumen E, Bianchi A, Kelly K, Campbell S, Hagrman D, Bagg R, Clement J, Wolfe AJ, Basso A, Nicoletti C, Lai G, Provinciali M, Malavolta M, Moody K. GeroScience. 2020.

Fenretinide Binding to the Lysosomal Protein Saposin D Alters Ceramide Solubilization and Hydrolysis. Milliken, B. T.; Melegari, L.; Smith, G. L.; Grohn, K.; Wolfe, A. J.; Moody, K.; Bou-Abdallah, F.; Doyle, R. P. RSC Med. Chem. 2020.

High-Throughput Screening of Protein-Detergent Complexes Using Fluorescence Polarization Spectroscopy.
Wolfe AJ, Parella KJ, Movileanu L.
Curr Protoc Protein Sci. 2019 Sep; 97(1):e96. doi: 10.1002/cpps.96.

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.
Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK9, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V.
Cell. 2019 Apr 18;177(3):622-638.e22. doi: 10.1016/j.cell.2019.03.043.

Recombinant Manganese Peroxidase Reduces A2E Burden in Age-Related and Stargardt's Macular Degeneration Models.
Moody KJ, Tinklepaugh J, Obert E, Grohn K, DeRosa JR, Lumen E, Moyer BS, Campbell S, Wolfe AJ, Sleeper MB, Bianchi AH, Fisher C, Applegate J, Leary E, LeClair N, Wortel D, Doyle RP, Rohrer B, Blanden AR.
Rejuvenation Res. 2018 Dec;21(6):560-571. doi: 10.1089/rej.2018.2146.

Kinetics of Membrane Protein-Detergent Interactions Depend on Protein Electrostatics.
Wolfe AJ, Gugel JF, Chen M, Movileanu L.
J Phys Chem B. 2018 Oct 18;122(41):9471-9481. doi: 10.1021/acs.jpcb.8b07889. Epub 2018 Oct 5.

RPtag as an Orally Bioavailable, Hyperstable Epitope Tag and Generalizable Protein Binding Scaffold.
DeRosa JR, Moyer BS, Lumen E, Wolfe AJ, Sleeper MB, Bianchi AH, Crawford A, McGuigan C, Wortel D, Fisher C, Moody KJ, Blanden AR.
Biochemistry. 2018 May 29;57(21):3036-3049. doi: 10.1021/acs.biochem.8b00170. Epub 2018 May 15.

Detergent Desorption of Membrane Proteins Exhibits Two Kinetic Phases.
Wolfe AJ, Gugel JF, Chen M, Movileanu L.
J Phys Chem Lett. 2018 Apr 19;9(8):1913-1919. doi: 10.1021/acs.jpclett.8b00549. Epub 2018 Apr 2.

Quantification of Membrane Protein-Detergent Complex Interactions.
Wolfe AJ, Si W, Zhang Z, Blanden AR, Hsueh YC, Gugel JF, Pham B, Chen M, Loh SN, Rozovsky S, Aksimentiev A, Movileanu L.
J Phys Chem B. 2017 Nov 9;121(44):10228-10241. doi: 10.1021/acs.jpcb.7b08045. Epub 2017 Oct 31.

Interrogating Detergent Desolvation of Nanopore-Forming Proteins by Fluorescence Polarization Spectroscopy.
Wolfe AJ, Hsueh YC, Blanden AR, Mohammad MM, Pham B, Thakur AK, Loh SN, Chen M, Movileanu L.
Anal Chem. 2017 Aug 1;89(15):8013-8020. doi: 10.1021/acs.analchem.7b01339. Epub 2017 Jul 10.

Global redesign of a native β-barrel scaffold.
Wolfe AJ, Mohammad MM, Thakur AK, Movileanu L.
Biochim Biophys Acta. 2016 Jan;1858(1):19-29. doi: 10.1016/j.bbamem.2015.10.006. Epub 2015 Oct 9.

Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore.
Blanden AR, Yu X, Wolfe AJ, Gilleran JA, Augeri DJ, O'Dell RS, Olson EC, Kimball SD, Emge TJ, Movileanu L, Carpizo DR, Loh SN. Mol Pharmacol. 2015 May;87(5):825-31. doi: 10.1124/mol.114.097550.

Cation selectivity is a conserved feature in the OccD subfamily of Pseudomonas aeruginosa.
Liu J, Wolfe AJ, Eren E, Vijayaraghavan J, Indic M, van den Berg B, Movileanu L.
Biochim Biophys Acta. 2012 Nov;1818(11):2908-16. doi: 10.1016/j.bbamem.2012.07.009. Epub 2012 Jul 21.

Facilitated translocation of polypeptides through a single nanopore.
Bikwemu R, Wolfe AJ, Xing X, Movileanu L.
J Phys Condens Matter. 2010 Nov 17;22(45):454117. doi: 10.1088/0953-8984/22/45/454117. Epub 2010 Oct 29.

Catalyzing the translocation of polypeptides through attractive interactions.
Wolfe AJ, Mohammad MM, Cheley S, Bayley H, Movileanu L.
J Am Chem Soc. 2007 Nov 14;129(45):14034-41. Epub 2007 Oct 19.